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Fat balance and hepatic mitochondrial function in response to fat feeding in mature rats

International Journal of Obesity volume 23, pages 1122–1128 (1999)Cite this article

Abstract

OBJECTIVE: To study the effects of fat feeding on fat balance and hepatic mitochondrial function in postpubertal male rats.

DESIGN: Rats were fed low fat, medium fat or high fat diet for 15 days.

MEASUREMENTS: Energy balance, body composition, resting metabolic rate (RMR), mitochondrial state 3 and state 4 oxygen consumption rates, succinic dehydrogenase (EC 1.3.99.1) and mitochondrial α-glycerophosphate dehydrogenase (EC 1.1.1.8) activities.

RESULTS: Rats fed medium fat or high fat diet, in comparison with rats fed low fat diet, showed a significantly greater metabolisable energy intake and energy expenditure. In addition, body energy and lipid gains were significantly higher in rats fed medium fat or high fat diet than in rats fed low fat diet. Mitochondrial respiration and enzymatic activities were not affected by fat feeding.

CONCLUSION: These results indicate that in postpubertal rats fed high fat diets, the increase in energy expenditure counteracts only in part the excess fat deposition. This is probably due to the impairment in regulatory responses, and enhances thermogenesis.

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Authors and Affiliations

  1. Department of General and Environmental Physiology, University of Naples ‘FEDERICO II’, Italy

    S Iossa, L Lionetti, M Pina Mollica, A Barletta & G Liverini

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  1. S Iossa
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  2. L Lionetti
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  3. M Pina Mollica
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  4. A Barletta
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  5. G Liverini
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Correspondence to G Liverini.

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Iossa, S., Lionetti, L., Pina Mollica, M. et al. Fat balance and hepatic mitochondrial function in response to fat feeding in mature rats. Int J Obes 23, 1122–1128 (1999). https://doi.org/10.1038/sj.ijo.0801041

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  • DOI: https://doi.org/10.1038/sj.ijo.0801041

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