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Association between indices of body mass and antibody titres to heat-shock protein-60, -65 and -70 in healthy Caucasians

International Journal of Obesity volume 31, pages 197–200 (2007)Cite this article

Abstract

We have previously shown that antibody titres to several heat-shock proteins (Hsps) are elevated in dyslipidaemic patients and subjects with established vascular disease. Obesity is known to be associated with raised serum inflammatory markers suggesting a state of heightened immune activation. Hence, we have investigated the association between indices of obesity and several Hsp antibody titres in healthy subjects. Subjects (n=170) were recruited from among employees at the University of Surrey and the Royal Surrey County Hospital, Guildford, UK. Of these subjects, 35 were obese with a body mass index (BMI)⩾30 kg/m2 (19 male and 16 female subjects), 58 were overweight with 30>BMI⩾25 kg/m2 (36 male and 22 female subjects) and 77 were of a normal weight with BMI<25 kg/m2 (31 male and 46 female subjects). Overall, obese subjects had significantly higher plasma anti-Hsp-60 (P<0.001), anti-Hsp-65 (P<0.05) and anti-Hsp-70 (P<0.05) compared with overweight and normal weight subjects.

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Acknowledgements

MGM is a scholar of the Iranian Government. DJL was partially supported by the British Heart Foundation and a Bridging Grant from the University of Surrey.

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Authors and Affiliations

  1. Centre for Clinical Science & Measurement, School of Biomedical & Molecular Science, University of Surrey, Guildford, Surrey, UK

    M Ghayour-Mobarhan, A Taylor, D J Lamb & G A A Ferns

  2. Faculty of Medicine, Mashad University of Medical Sciences, Mashad, Iran

    M Ghayour-Mobarhan

  3. Department of Clinical Biochemistry, The Royal Surrey County Hospital, Guildford, Surrey, UK

    A Taylor & G A A Ferns

Authors
  1. M Ghayour-Mobarhan
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  2. A Taylor
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  3. D J Lamb
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  4. G A A Ferns
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Correspondence to G A A Ferns.

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Ghayour-Mobarhan, M., Taylor, A., Lamb, D. et al. Association between indices of body mass and antibody titres to heat-shock protein-60, -65 and -70 in healthy Caucasians. Int J Obes 31, 197–200 (2007). https://doi.org/10.1038/sj.ijo.0803385

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