Table a1 Summary of excluded studies

From: Prevalence and clinical implications of the inter-arm blood pressure difference: a systematic review

Reference (country of origin)

Study population

Reason for exclusion

Sample size

Prevalence of systolic differences

Prevalence of diastolic differences

Phipps (1915)34 (USA)

Mixed in-patients

Sequential measurements

36

20%10 mm Hg

Not stated

Cyriax (1918)35 (UK)

War wounded

Sequential measurements

36

72%>5 mm Hg

Not stated

Cyriax (1920)2 (UK)

Post-Surgical in-patients

Many war trauma.

Mainly with ‘unilateral’ wounds

Sequential measurements

73

83%10 mm Hg

20%20 mm Hg

81%10 mm Hg

12%20 mm Hg

Cyriax (1921)33 (UK)

Private practice (93) and in-patients (35):

Unilateral or bilaterally unequal surgical cases

Sequential measurements

128

56

‘Confirmed previous findings’

‘Confirmed previous findings’

 

Bilaterally equal and constitutional disorders

 

78

35%10 mm Hg

7%20 mm Hg

45%10 mm Hg

4%20 mm Hg

Kay and Gardner (1930)38 (USA)

General medical practice, opportunistic sample

Sequential measurements

125

12% >20 mm Hg

13% >10 mm Hg

Korns and Guinand (193l)31 (USA)

Healthy University students, 73% male, mean age 20

Simultaneous but single pair of measurements

1000

22.2%10 mm Hg

21.7%10 mm Hg

Southby (1935)53 (Australia)

Patients attending one general practice

Sequential measurements

516

Differences above 20 mm systolic or 10 mm diastolic in 60% of cases

 

Israel (1944)39

Hypertensives, population not defined

Sequential measurements

125

18.4% >20 mm Hg

2.4% >10 mm Hg

Rueger (1951)54 (USA)

Office patients

Sequential measurements

755

50%>10 mm Hg

13.6% >20 mm Hg

33.7% >10 mm Hg

Swallow (1975)(letter)50 (UK)

General practice, 50–54 year old males

Measurement technique not stated

33

76%10 mm Hg

 

Kristensen and Kornerup (1982)43 (Denmark)

Highly selected normotensive patients without signs of CVD

Unselected normotensive in-patients

Hypertensive out-patients

Hypertensive out-patients

Sequential measurements

55

23

57

62

34.5%10 mm Hg

3.4%20 mm Hg

60.9%10 mm Hg

26.1%20 mm Hg

49.1%10 mm Hg

15.8%20 mm Hg

5.2%30 mm Hg

59.7%10 mm Hg

25.8%20 mm Hg

8.1%30 mm Hg

14.5%10 mm Hg

43.5%10 mm Hg

8.7%20 mm Hg

29.8%10 mm Hg

5.2%20 mm Hg

1.8%30 mm Hg

37.1%10 mm Hg

12.9%20 mm Hg

1.6%30 mm Hg

Hashimoto et al. (1984)42 (USA)

Elderly residential home residents attending for BP checks. 50% were hypertensive

Sequential measurements

174

20%10 mm Hg

3.4%20 mm Hg

9.7%10 mm Hg

Gould et al. (1985)46 (UK)

Hypertensives

Simultaneous random zero measurements with two observers

91

Dismissed differences over 20 mm as erroneous, found no apparent mean differences over 10 mm systolic or diastolic. Individual measured differences were 8% readings >10 mm Hg systolic and 3% diastolic. Concluded that no bias is introduced by making measurements in different arms

 

Goldhill (1986)47 (USA)

Not stated

One observer listening to bilateral dopplers

Review of recordings of dopplers and pressures

52

68

37%6 mm Hg

13%11 mm Hg

6%6 mm Hg

None>9 mm Hg

 

Yagi et al. (1986)45 (Japan)

Convalescent stroke in-patients

Simultaneous automated measurements

47

Mean 131/83 in paretic arms, 129/78 in intact arms, P<0.01/P<0.001

 

Frank et al. (1991)36 (USA)

Peripheral vascular disease in-patients

Coronary heart disease in-patients

Controls: orthopaedic & urology in-patients

Sequential measurements

58

38

38

21%20 mm Hg

41%10 mm Hg

16%10 mm Hg

3%20 mm Hg

13%10 mm Hg

0%20 mm Hg

31%10 mm Hg

4%15 mm Hg

5%10 mm Hg

3%15 mm Hg

5%10 mm Hg

3%15 mm Hg

Fotherby et al. (1993)41 (UK)

Elderly in & out-patients

Young in & out-patients

Simultaneous automated measurements

40

40

10%>10 mm Hg

None

None

Panayiotou et al. (1993)48 (UK)

Hemiplegic in-patients following acute stroke

Simultaneous automated measurements

15

No correlation with side of paresis, mean inter-arm difference 4.4/4.7 mm Hg

 

Singer and Hollander (1996)55 (USA)

Ambulant patients over 5 years old attending university hospital emergency department

Sequential measurements

Single (not repeated) simultaneous automated indirect

300

310

13.3%>20 mm Hg

11.6% >20 mm Hg

28%>10 mm Hg

20.6% >10 mm Hg

O’Shea and Murphy (2000)49 (Ireland)

Patients attending for ambulatory BP monitoring

Sequential measurements

39

33%10 mm Hg

 

Clark (2001)59 (UK)

General practice

Sequential measurements

205

31%10 mm Hg

4%20 mm Hg

13%10 mm Hg

Cassidy and Jones (2001)56 (UK)

General practice

Sequential measurements

237

23%20 mm Hg

40%10 mm Hg

Pesola et al. (2001)44 (USA)

Normotensive patients attending ER and staff accepting BP screening

Sequential measurements

100

15%10 mm Hg

 

Clark and Powell (2002)20 (UK)

General practice

Sequential measurements

280

40.7%10 mm Hg

13.6%20 mm Hg

23.2%10 mm Hg

Pesola et al. (2002)57 (USA)

Staff and visitors to an ER with history of hypertension willing to be screened

Sequential measurements

100

18%10 mm Hg

 

Shadman et al. (2004)29 (USA)

General population

Vascular patients

Sequential measurements

2975

1248

1.9%>15 mm Hg

7.1%>15 mm Hg

Not stated

Not stated

Arnett et al. (2005)58 (USA)

Random population sample

Hypertensive siblings

Sequential measurements

824

2195

9.2%>10 mm Hg

1.1%>20 mm Hg

14.2%>10 mm Hg

1.8%>20 mm Hg

1.6%>10 mm Hg

0>20 mm Hg

2.8%>10 mm Hg

0.1%>20 mm Hg