Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Short Report
  • Published:

Avian winged helix proteins CWH-1, CWH-2 and CWH-3 repress transcription from Qin binding sites

Oncogene volume 15, pages 483–488 (1997)Cite this article

Abstract

The chicken winged helix proteins, CWH-1, CWH-2 and CWH-3, were isolated and identified by homology cloning using the winged helix sequence of the retroviral oncogene qin as a probe. The CWH proteins act as growth stimulators in chicken embryo fibroblasts and in this activity resemble the Qin protein. Qin is a transcriptional regulator that functions as a repressor, and its oncogenic potential is correlated with the ability to repress transcription. In this communication we show that CWH proteins are localized in the cell nucleus, recognize the Qin DNA binding site and also function as transcriptional repressors. The repression activity of CWH-3 was mapped to the region of amino acids 211 to 311, a domain that is homologous to the major repression domain of Qin.

Access through your institution
Buy or subscribe

This is a preview of subscription content, access via your institution

Access options

Access through your institution

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

Author information

Author notes

  1. Bettina S Freyaldenhoven, Markus P Freyaldenhoven, Jason S Iacovoni & Peter K Vogt

    Present address: Department of Hematology/Oncology, University of Freiburg, Hugstetterstr. 55, Freiburg, 79106, Germany

  2. Markus P Freyaldenhoven: Markus P Freyaldenhoven died on December 22, 1996 after a long struggle with cancer. His life's work was deveoted to the eradication of this disease. Markus was a gentle and kind man, with great courage and strength and a deep love for science. We remember him and miss him.

Authors and Affiliations

  1. Division of Oncovirology, Department of Molecular & Experimental Medicine, The Scripps Research Institute, BCC239, 10550 N. Torrey Pines Road, La Jolla, 92037, California, USA

    Bettina S Freyaldenhoven, Markus P Freyaldenhoven, Jason S Iacovoni & Peter K Vogt

Authors
  1. Bettina S Freyaldenhoven
    View author publications

    Search author on:PubMed Google Scholar

  2. Markus P Freyaldenhoven
    View author publications

    Search author on:PubMed Google Scholar

  3. Jason S Iacovoni
    View author publications

    Search author on:PubMed Google Scholar

  4. Peter K Vogt
    View author publications

    Search author on:PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Freyaldenhoven, B., Freyaldenhoven, M., Iacovoni, J. et al. Avian winged helix proteins CWH-1, CWH-2 and CWH-3 repress transcription from Qin binding sites. Oncogene 15, 483–488 (1997). https://doi.org/10.1038/sj.onc.1201189

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue date:

  • DOI: https://doi.org/10.1038/sj.onc.1201189

Keywords

This article is cited by

Search

Advanced search

Quick links