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Heritable lympho-epithelial thymoma resulting from a transgene insertional mutation

Oncogene volume 19, pages 32–38 (2000)Cite this article

Abstract

Thymoma is the most common tumor of the anterior-superior mediastinum. We have identified a line of transgenic mice which spontaneously and heritably develop thymomas at a very high penetrance. The available data suggest that thymoma formation in these mice results as a consequence of transgene insertional mutagenesis. Immune histologic analyses indicate that the thymomas are of epithelial cell origin. Survival studies indicate that tumor progression is more aggressive in females as compared to males (73.9 vs 41.7% mortality at 20 weeks of age, respectively). Fluorescent in situ hybridizations have localized the transgene integration site to the F2-G region of mouse chromosome 2. Translocation encompassing the syntenic region in humans has been implicated in lympho-epithelial thymoma. These animals may constitute a useful resource for the identification of gene(s) which participate in thymoma progression, as well as a model system for screening anti-thymoma therapeutic agents.

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Acknowledgements

We thank He Wang and Dorothy Field for excellent technical assistance, and Drs Laura Pajak and Kishore Pasumarthi for comments on the manuscript. This work was supported by the NHLBI (LJ Field), by a grant from Bristol-Myers Squibb, and by the William P Loehrer Family Fund.

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Authors and Affiliations

  1. Herman B Wells Center for Pediatric Research Indiana University School of Medicine, Riley Hospital, 702 Barnhill Drive, Room 2600, Indianapolis, 46202-5225, Indiana, IN, USA

    Hidehiro Nakajima, Hisako O Nakajima, Mark H Soonpaa, Shaoliang Jing & Loren J Field

  2. Krannert Institute of Cardiology, Indiana University School of Medicine, Riley Hospital, 702 Barnhill Drive, Room 2600, Indianapolis, 46202-5225, Indiana, IN, USA

    Hidehiro Nakajima, Hisako O Nakajima, Mark H Soonpaa, Shaoliang Jing & Loren J Field

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  1. Hidehiro Nakajima
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  2. Hisako O Nakajima
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Nakajima, H., Nakajima, H., Soonpaa, M. et al. Heritable lympho-epithelial thymoma resulting from a transgene insertional mutation. Oncogene 19, 32–38 (2000). https://doi.org/10.1038/sj.onc.1203266

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