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Review Article

Potential roles of antisense technology in cancer chemotherapy

Oncogene volume 19, pages 6651–6659 (2000)Cite this article

Abstract

Antisense technology may play a major role in cancer chemotherapy. It is clearly a tool of exceptional value in the functionalization of genes and their validation as potential targets for cancer chemotherapy. Additionally, there is now substantial evidence that antisense drugs are safe, and a growing body of data showing activity in animal models of human disease including cancer, and suggesting efficacy in patients with cancer. In this article, I review the progress in the technology, the anticancer antisense drugs in development and potential roles that antisense technology might play.

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Acknowledgements

Thanks to Ms Donna Musacchia for# excellent administrative assistance and to Drs Andy Dorr, Jon Holmlund and Scott Henry for allowing me to cite their unpublished work.

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  1. Isis Pharmaceuticals, Inc, 2292 Faraday Avenue, Carlsbad, CA 92008, California, USA

    Stanley T Crooke

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  1. Stanley T Crooke
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Crooke, S. Potential roles of antisense technology in cancer chemotherapy. Oncogene 19, 6651–6659 (2000). https://doi.org/10.1038/sj.onc.1204093

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