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  • Oncogenomics
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Five new mouse susceptibility to colon cancer loci, Scc11–Scc15

Oncogene volume 22, pages 7258–7260 (2003)Cite this article

Abstract

Although several genes causing familial cancer syndromes have been identified, susceptibility to sporadic cancer remains unsolved. Animal experiments have demonstrated a large number of quantitative trait loci affecting cancer susceptibility. Previously, we described in mouse strain CcS-19/Dem five susceptibility to colon cancer (Scc) loci, Scc1–Scc5 controlling tumor numbers. In the present study, we performed an independent identical mouse cross using a distinct carcinogen, azoxymethane, to induce colon tumors. We confirmed all five originally described Scc loci and detected five additional new Scc loci; Scc11–Scc15. All these loci were detected in two-way interactions.

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Abbreviations

AOM:

azoxymethane

Scc :

susceptibility to colon cancer

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Acknowledgements

We thank Joost de Moes, Elly Delzenne-Goette, and Marcelle Treur for excellent technical assistance. We appreciate the many discussions of the statistical analysis with Dr Nikos Tripodis and Dr G Hart. This work was supported by Dutch Cancer Society Grants NKI 97-1436 and NKI 98-1832.

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Author notes

  1. Claudia A L Ruivenkamp

    Present address: Department of Human and Clinical Genetics, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands

  2. Tom van Wezel

    Present address: Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands

  3. Peter Demant

    Present address: Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY, USA

Authors and Affiliations

  1. Division of Molecular Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066CX, The Netherlands

    Claudia A L Ruivenkamp, Tamás Csikós, Anita M Klous, Tom van Wezel & Peter Demant

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  1. Claudia A L Ruivenkamp
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  2. Tamás Csikós
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  3. Anita M Klous
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  4. Tom van Wezel
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  5. Peter Demant
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Correspondence to Peter Demant.

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Ruivenkamp, C., Csikós, T., Klous, A. et al. Five new mouse susceptibility to colon cancer loci, Scc11–Scc15. Oncogene 22, 7258–7260 (2003). https://doi.org/10.1038/sj.onc.1207096

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