Abstract
Many trophic factors are now thought to also function in maintenance of the adult brain. We hypothesized that since serotonin plays a role in synaptogenesis, it may also function in maintenance of synapses in the adult. Adult rats were depleted of serotonin with the tryptophan hydroxylase inhibitor p-chlorophenylalanine (PCPA) for 10 days. Fourteen days after the final treatment, immunodensitometry showed a significant decrease in the synaptic marker, MAP-2. Our results are discussed in respect to the recent finding of decreased MAP-2 staining in postmortem schizophrenic brains.
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Whitaker-Azmitia, P., Borella, A. & Raio, N. Serotonin Depletion in the Adult Rat Causes Loss of the Dendritic Marker MAP-2. Neuropsychopharmacol 12, 269–272 (1995). https://doi.org/10.1016/0893-133X(94)00081-A
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DOI: https://doi.org/10.1016/0893-133X(94)00081-A
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