Abstract
To investigate the effect on the sleep EEG, a 1-mg oral dose of SR 46349B, a novel 5-HT2 antagonist, was administered three hours before bedtime. The drug enhanced slow wave sleep (SWS) and reduced stage 2 without affecting subjective sleep quality. In nonREM sleep (NREMS) EEG slow-wave activity (SWA; power within 0.75–4.5 Hz) was increased and spindle frequency activity (SFA; power within 12.25–15 Hz) was decreased. The relative NREMS power spectrum showed a bimodal pattern with the main peak at 1.5 Hz and a secondary peak at 6 Hz. A regional analysis based on bipolar derivations along the antero-posterior axis revealed significant ‘treatment’ × ‘derivation’ interactions within the 9–16 Hz range. In enhancing SWA and attenuating SFA, the 5-HT2 receptor antagonist mimicked the effect of sleep deprivation, whereas the pattern of the NREMS spectrum differed.
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Acknowledgements
We thank Dr. Corinne Roth for her assistance with the experiment and Dr. Irene Tobler for comments on the manuscript. This research was supported by SANOFI Recherche, the Swiss National Science Foundation (Grant Nr. 3100–042500.94 and 3100–053005.97) and the Human Frontiers Science Program RG 81/96.
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Landolt, HP., Meier, V., Burgess, H. et al. Serotonin-2 Receptors and Human Sleep: Effect of a Selective Antagonist on EEG Power Spectra. Neuropsychopharmacol 21, 455–466 (1999). https://doi.org/10.1016/S0893-133X(99)00052-4
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DOI: https://doi.org/10.1016/S0893-133X(99)00052-4
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