Abstract
Several lines of evidence indicate that a variety of metabolic stressors, including acute glucose deprivation are associated with dopamine release. Pharmacologic doses of the glucose analogue, 2-deoxyglucose (2DG) cause acute glucoprivation and are associated with enhanced dopamine turnover in preclinical studies. In this study, we utilized [11C]raclopride PET to examine 2DG-induced striatal dopamine release in healthy volunteers. Six healthy volunteers underwent PET scans involving assessment of 2DG-induced (40 mg/kg) decrements in striatal binding of the D2/D3 receptor radioligand [11C]raclopride. Decreases in [11C]raclopride specific binding reflect 2DG-induced changes in synaptic dopamine. Specific binding significantly decreased following 2DG administration, reflecting enhanced synaptic dopamine concentrations (p = .02). The administration of 2DG is associated with significant striatal dopamine release in healthy volunteers. Implications of these data for investigations of the role of stress in psychiatric disorders are discussed.
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Adler, C., Elman, I., Weisenfeld, N. et al. Effects of Acute Metabolic Stress on Striatal Dopamine Release in Healthy Volunteers. Neuropsychopharmacol 22, 545–550 (2000). https://doi.org/10.1016/S0893-133X(99)00153-0
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DOI: https://doi.org/10.1016/S0893-133X(99)00153-0
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