Abstract
The effects of N-[1-(2-benzo[b]thiophenyl)cyclohexyl]- piperidine (BTCP), a phencyclidine derivative that acts as a potent dopamine reuptake inhibitor, were examined on cocaine self-administration in rats. The effects of BTCP (0, 4, 8, 16, and 32 mg/kg, i.p.) on cocaine self-administration were tested against cocaine doses on both the ascending (0.0625 mg/infusion) and descending (0.25 mg/infusion) limb of the dose-response function. BTCP decreased self-administration of the 0.25-mg cocaine dose in a dose-dependent manner. A 16-mg/kg dose of BTCP that strongly suppressed self-administration of the 0.25-mg cocaine dose increased the intake at the 0.0625-mg dose of cocaine. Moreover, cocaine and BTCP pretreatments produced similar patterns of decreases in self-administration of cocaine on the descending limb of the dose-response function. The results suggest that BTCP has cocaine-like actions and produces a leftward shift of the dose-response curve for cocaine self-administration, indicating that the phencyclidine analog may substitute under certain conditions for the reinforcing effects of cocaine in self-administering rats.
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Acknowledgements
This is publication number 12098-NP from The Scripps Research Institute. This work was supported by NIDA grant DA07348 (FW), and by a fellowship from Singer Polignac and Simone et Cino Del Duca Fondations (RMF). The authors thank Martine Michaud for the synthesis of BTCP, Diana Smith for technical assistance and Mike Arends for assistance with the preparation of the manuscript.
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Martin-Fardon, R., Weiss, F. N-[1-(2-Benzo[b]Thiophenyl)Cyclohexyl]- Piperidine (BTCP) Exerts Cocaine-Like Actions on Drug-Maintained Responding in Rats. Neuropsychopharmacol 23, 316–325 (2000). https://doi.org/10.1016/S0893-133X(00)00104-4
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DOI: https://doi.org/10.1016/S0893-133X(00)00104-4
