Table 1 Startle magnitude, habituation, and NO STIM activity in adult SDH and WH rats
Startle Magnitude (mean (SEM)) | Habituation (startle magnitude (mean (SEM)) in Blocks 1 and 4) | ||||||
|---|---|---|---|---|---|---|---|
Dose DOI (mg/kg) | N | Block 2 | Block 3 | Block 1 | Block 4 | % Habituation | NO STIM (mean (SEM)) |
SDH rats | |||||||
Veh | 7 | 289.11 (127.03) | 343.04 (128.08) | 1004.86 (228.27) | 364.24 (114.2) | 64.98 | 0.002 (.002) |
0.10 | 7 | 289.61 (41.98) | 253.14 (58.25) | 999.21 (122.72) | 219.43 (42.54) | 74.95 | 0.480 (.302) |
0.25 | 7 | 401.20 (87.05) | 341.59 (39.82) | 1031.32 (181.52) | 337.81 (78.65) | 54.37 | 0.828 (.434) |
0.50 | 6 | 373.81 (67.10) | 266.67 (48.36) | 861.04 (208.06) | 299.00 (37.00) | 51.64 | 0.972 (.323) |
1.00 | 7 | 363.57 (65.67) | 313.38 (68.72) | 576.93 (122.31) | 309.48 (65.23) | 43.98 | 1.221 (.352) |
WH rats | |||||||
Veh | 9 | 420.99 (165.14) | 271.57 (70.07) | 761.50 (105.54) | 317.85 (95.05) | 61.75 | 0.036 (.021) |
0.10 | 8 | 372.92 (41.20) | 340.84 (32.29) | 779.63 (147.27) | 210.67 (36.73) | 63.8 | 0.848 (.413) |
0.25 | 8 | 200.39 (35.77) | 217.22 (35.69) | 582.00 (92.97) | 164.58 (34.67) | 70.97 | 0.886 (.496) |
0.50 | 8 | 237.42 (38.31) | 211.70 (50.99) | 662.50 (132.37) | 213.92 (39.96) | 61.57 | 0.928 (.429) |
1.00 | 8 | 174.20 (30.48) | 148.80 (39.95) | 470.09 (78.74) | 142.96 (39.57) | 67.93 | 1.414 (.588) |
