Table 2 Startle magnitude, habituation, and NO STIM activity in male and female SDH pups
Startle Magnitude (mean (SEM)) | Habituation (startle magnitude (mean (SEM)) in Blocks 1 and 4) | ||||||
|---|---|---|---|---|---|---|---|
Dose DOI (mg/kg) | N | Block 2 | Block 3 | Block 1 | Block 4 | % Habituation | NO STIM (mean (SEM)) |
Males | |||||||
Veh | 9 | 54.40 (10.47) | 50.68 (9.73) | 102.42 (11.92) | 53.41 (9.92) | 43.21 | 0.198 (.124) |
0.10 | 8 | 64.86 (8.85) | 61.22 (12.07) | 91.19 (11.62) | 63.00 (10.86) | 31.32 | 0.057 (.038) |
0.25 | 8 | 68.27 (8.60) | 49.73 (8.64) | 103.44 (14.99) | 57.21 (10.71) | 44.03 | 0.543 (.398) |
0.50 | 8 | 59.81 (8.13) | 61.27 (10.02) | 103.22 (12.40) | 56.79 (10.46) | 35.49 | 0.631 (.128) |
1.00 | 8 | 59.95 (5.74) | 58.19 (8.16) | 103.13 (12.44) | 53.04 (4.50) | 44.59 | 0.512 (.174) |
Females | |||||||
Veh | 9 | 57.24 (6.58) | 47.56 (6.25) | 102.69 (7.49) | 64.85 (9.93) | 37.5 | 0.052 (.031) |
0.10 | 9 | 27.43 (5.52) | 33.44 (7.22) | 74.53 (16.51) | 31.30 (7.53) | 46.78 | 0.200 (.110) |
0.25 | 9 | 50.01 (10.09) | 35.49 (6.31) | 89.33 (15.69) | 25.93 (4.51) | 65.53 | 0.094 (.034) |
0.50 | 8 | 56.95 (12.39) | 48.05 (12.02) | 46.01 (16.27) | 40.00 (6.85) | 47.02 | 0.480 (.146) |
1.00 | 9 | 62.08 (6.66) | 48.32 (6.35) | 97.06 (12.64) | 46.63 (6.50) | 34.75 | 0.338 (.075) |
