Abstract
The use of neonatal ventral hippocampal nVH lesioned rats is well established in animal models of schizophrenia. Moreover, the dysfunction of N-methyl-D-aspartate (NMDA) neurotransmission may play a crucial role in the pathophysiology of schizophrenia. To examine the effect of glycine (GLY) in this animal model, we compared the effects of GLY (0.8 and 1.6 g/kg, IP) on locomotor activity induced by a novel environment (NOVEL) and methamphetamine (MAP, 1.5 mg/kg, IP) in lesioned and sham-operated rats. Compared with sham rats, GLY significantly reduced NOVEL- and MAP-induced locomotor activity in lesioned rats (p < .001 and p < .05, respectively). It is suggested that GLY attenuated nVH-induced hyperactivity, and that this effect was evident both in the presence and absence of MAP. The nVH lesions may result in a form of hyperactivity that differs from normal locomotion in the degree to which it is highly sensitive to regulation by GLY.
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Kato, K., Shishido, T., Ono, M. et al. Glycine Reduces Novelty- and Methamphetamine-Induced Locomotor Activity in Neonatal Ventral Hippocampal Damaged Rats. Neuropsychopharmacol 24, 330–332 (2001). https://doi.org/10.1016/S0893-133X(00)00213-X
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DOI: https://doi.org/10.1016/S0893-133X(00)00213-X
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