Abstract
Striatal enlargement has been consistently reported in schizophrenics receiving chronic neuroleptic treatment although the results following atypical antipsychotic treatment have been equivocal. In order to disentangle patient illness from a possible drug effect on brain structure, young adult rats were administered either haloperidol, risperidone, clozapine, olanzapine, or vehicle daily for four or eight months via drinking water. Significant increases in caudate-putamen volumes were seen in animals receiving either haloperidol or clozapine when compared with control animals following eight months of drug administration. Conversely, olanzapine-treated animals showed significant decreases in caudate-putamen volumes when compared with control animals after eight months of drug. Thus, converging evidence indicates that the neuroplastic response of the striatum following neuroleptic exposure causes volumetric increases, whereas atypical antipsychotics affect the basal ganglia differentially. The current data suggests that such differential responses may be due to both the pharmacological properties and the relative doses of the atypical agents.
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Acknowledgements
This research was supported by T32 ESO7126, and grants from the Foundation of Hope, the Theodore and Vada Stanley Foundation, and Eli Lilly and Company. The authors would like to thank MacNeil Pharmaceuticals for the gift of haloperidol, Novartis Pharmaceuticals for the gift of clozapine, Janssen Pharmaceutica for the gift of risperidone, and Eli Lilly, Inc., for the gift of olanzapine.
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Andersson, C., Hamer, R., Lawler, C. et al. Striatal Volume Changes in the Rat Following Long-term Administration of Typical and Atypical Antipsychotic Drugs. Neuropsychopharmacol 27, 143–151 (2002). https://doi.org/10.1016/S0893-133X(02)00287-7
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DOI: https://doi.org/10.1016/S0893-133X(02)00287-7
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