Abstract
This study attempted to replicate previous findings of decreased gray matter content in the subgenual prefrontal cortex (SGPFC) in mood disorder patients. Eighteen DSM-IV unipolar patients, 27 DSM-IV bipolar patients, and 38 healthy controls were studied. A 1.5T GE Signa Imaging System with Signa 5.4.3 software was used. The semi-automated software MedX (Sensor Systems, Sterling, VA) was utilized for the anatomical measures of SGPFC volumes. There were no significant differences in SGPFC volumes in familial and non-familial unipolar and bipolar patients compared with healthy controls, nor between drug-free and lithium-treated bipolar patients (ANOVA, p> .05). In vivo abnormalities in the volumes of SGPFC were not identified in mildly depressed or euthymic unipolar or bipolar mood disorder outpatients, either familial or non-familial.
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References
Bech P, Bolwig PG, Kromp P, Rafaelsen OJ . (1979): The Bech-Rafaelsen Mania Scale and the Hamilton depression scale. Acta Psychiatrica Scandinavica 59: 420–430
Brambilla P, Harenski K, Nicoletti M, Mallinger AG, Frank E, Kupfer DJ, Keshavan MS, Soares JC . (2001a): Differential age effects in brain gray matter in bipolar patients and healthy controls. Neuropsychobiology 43: 242–247
Brambilla P, Harenski K, Nicoletti M, Mallinger AG, Frank E, Kupfer DJ, Keshavan MS, Soares JC . (2001b): Anatomical MRI study of basal ganglia in bipolar disorder patients. Psychiatry Research: Neuroimaging 106: 65–80
Brambilla P, Harenski K, Nicoletti M, Mallinger AG, Frank E, Kupfer DJ, Keshavan MS, Soares JC . (2001c): Anatomical MRI study of posterior fossa structures and brain ventricles in bipolar disorder patients. J Psychiatr Res 35: 313–322
Caetano SC, Sassi R, Brambilla P, Harenski K, Nicoletti M, Mallinger AG, Frank E, Kupfer DJ, Keshavan MS, Soares JC . (2001): MRI study of thalamic volumes in bipolar and unipolar patients and healthy individuals. Psychiatry Research: Neuroimaging 108: 161–168
Chen G, Rajkowska G, Du F, Seraji-Bozorgzad N, Manji HK . (2000): Enhancement of hippocampal neurogenesis by lithium. J Neurochem 75: 1729–1734
Chen RW, Chuang DM . (1999): Long-term lithium treatment suppresses p53 and Bax expression but increases Bcl-2 expression. A prominent role in neuroprotection against excitotoxicity. J Biol Chem 274: 6039–6042
Coffey CE, Wilkinson WE, Weiner RD, Parashos IA, Djang WT, Webb MC, Figiel GS, Spritzer CE . (1993): Quantitative cerebral anatomy in depression. A controlled magnetic resonance imaging study. Arch Gen Psychiatry 50: 7–16
Coffman JA, Bornstein RA, Olson SC, Schwarzkopf SB, Nasrallah HA . (1990): Cognitive impairment and cerebral structure by MRI in bipolar disorder. Biol Psychiatry 27: 1188–1196
Damasio AR, Tranel D, Damasio H . (1990): Individuals with sociopathic behavior caused by frontal damage fail to respond autonomically to social stimuli. Behav Brain Res 41: 81–94
Drevets WC . (2000): Neuroimaging studies of mood disorders. Biol Psychiatry 48: 813–829
Drevets WC, Price JL, Simpson JR Jr, Todd RD, Reich T, Vannier M, Raichle ME . (1997): Subgenual prefrontal cortex abnormalities in mood disorders. Nature 386: 824–827
Drevets WC, Raichle ME . (1992): Neuroanatomical circuits in depression: implications for treatment mechanisms. Psychopharmacol Bull 28: 261–274
Hamilton M . (1960): A rating scale for depression. J Neurol Neurosurg Psychiatry 23: 56–62
Hirayasu Y, Shenton ME, Salisbury DF, Kwon JS, Wible CG, Fischer IA, Yurgelun-Todd D, Zarate C, Kikinis R, Jolesz FA, McCarley RW . (1999): Subgenual cingulate cortex volume in first-episode psychosis. Am J Psychiatry 156: 1091–1093
Krishnan KR, McDonald WM, Escalona PR, Doraiswamy PM, Na C, Husain MM, Figiel GS, Boyko OB, Ellinwood EH, Nemeroff CB . (1992): Magnetic resonance imaging of the caudate nuclei in depression. Preliminary observations. Arch Gen Psychiatry 49: 553–557
Manji HK, Moore GJ, Chen G . (2000): Lithium up-regulates the cytoprotective protein Bcl-2 in the CNS in vivo: a role for neurotrophic and neuroprotective effects in manic-depressive illness. J Clin Psychiatry 61: 82–96
Ongur D, Drevets WC, Price JL . (1998): Glial reduction in the subgenual prefrontal cortex in mood disorders. Proc Natl Acad Sci USA 95: 13290–13295
Rajkowska G, Miguel-Hidalgo JJ, Wei J, Dilley G, Pittman SD, Meltzer HY, Overholser JC, Roth BL, Stockmeier CA . (1999): Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression. Biol Psychiatry 45: 1085–1098
Sassi RB, Nicoletti M, Brambilla P, Harenski K, Mallinger AG, Frank E, Kupfer DJ, Keshavan MS, Soares JC . (2001): Decreased pituitary volume in bipolar patients. Biol Psychiatry 50: 271–280
Sax KW, Strakowski SM, Zimmerman ME, DelBello MP, Keck PE Jr, Hawkins JM . (1999): Frontosubcortical neuroanatomy and the continuous performance test in mania. Am J Psychiatry 156: 139–141
Schlaepfer TE, Harris GJ, Tien AY, Peng LW, Lee S, Federman EB, Chase GA, Barta PE, Pearlson GD . (1994): Decreased regional cortical gray matter volume in schizophrenia. Am J Psychiatry 151: 842–848
Soares JC, Mann JJ . (1997): The anatomy of mood disorders–review of structural neuroimaging studies. Biol Psychiatry 41: 86–106
Spitzer RL, Williams JBW, Gibbon M, Williams JBW . (1994): Structured Clinical Interview for DSM-III-R (SCID). Washington, DC, American Psychiatric Press
Strakowski SM, DelBello MP, Adler C, Cecil KM, Sax KW . (2000): Neuroimaging in bipolar disorder. Bipolar Disorders 2: 148–164
Strakowski SM, DelBello MP, Sax KW, Zimmerman ME, Shear PK, Hawkins JM, Larson ER . (1999): Brain magnetic resonance imaging of structural abnormalities in bipolar disorder. Arch Gen Psychiatry 56: 254–260
Strakowski SM, Wilson DR, Tohen M, Woods BT, Douglass AW, Stoll AL . (1993): Structural brain abnormalities in first-episode mania. Biol Psychiatry 33: 602–609
Acknowledgements
This study was supported by grants MH 01736, MH 29618, and MH 30915 from the National Institute of Mental Health, the Theodore and Vada Stanley Foundation, NARSAD, American Foundation for Suicide Prevention, and CAPES Foundation (Brazil). Dr. Soares was the 1999-2001 Selo NARSAD Investigator.
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Brambilla, P., Nicoletti, M., Harenski, K. et al. Anatomical MRI Study of Subgenual Prefrontal Cortex in Bipolar and Unipolar Subjects. Neuropsychopharmacol 27, 792–799 (2002). https://doi.org/10.1016/S0893-133X(02)00352-4
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DOI: https://doi.org/10.1016/S0893-133X(02)00352-4
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