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d-Glyceric Aldehyde and Tumour Glycolysis

Nature volume 141, page 288 (1938)Cite this article

Abstract

IT was found some years ago1 that dl-glyceric aldehyde inhibits glycolysis of tumour cells. Anærobic glycolysis is inhibited about 75 per cent by 10-3 M., whereas aerobic glycolysis is not affected by this concentration. Aerobically, it takes four times this amount to produce the same effect. Concentrations higher than 4 × 10-3 M. of the aldehyde are toxic.

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References

  1. Mendel, B., Klin. Woch., 8, 169 (1929).

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  2. Needham, J., and Lehmann, H., NATURE, 140, 198 (1937). Biochem. J., 31, 1210, 1913 (1937).

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Authors and Affiliations

  1. Department of Medical Research, Banting Institute, University of Toronto,

    BRUNO MENDEL, FRIDA STRELITZ & DOROTHY MUNDELL

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  1. BRUNO MENDEL
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  2. FRIDA STRELITZ
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  3. DOROTHY MUNDELL
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MENDEL, B., STRELITZ, F. & MUNDELL, D. d-Glyceric Aldehyde and Tumour Glycolysis. Nature 141, 288 (1938). https://doi.org/10.1038/141288a0

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