Abstract
IN a previous communication1 we described the œstrogenic activity of 4: 4'-dihydroxy-α: β-diethylstilbene (diethylstilbœstrol). It was shown that this substance was fully œstrogenic in doses of 0·004 mgm. given subcutaneously dissolved in oil, and 0·001 mgm. when given by mouth. It is thus several times more potent than œstrone and at least as potent as œstradiol. The following communication is concerned with the activity of a series of compounds in which substituents other than the ethyl group are attached to the α and β carbon atoms. The method of testing was on ovariectomized rats by the usual technique.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Dodds, Golberg, Lawson and Robinson, NATURE, 141, 247 (1938).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
DODDS, E., GOLBERG, L., LAWSON, W. et al. Œstrogenic Activity of Alkylated Stilœstrols. Nature 142, 34 (1938). https://doi.org/10.1038/142034a0
Issue date:
DOI: https://doi.org/10.1038/142034a0
This article is cited by
-
Synthetic œstrogens in treatment
The Irish Journal of Medical Science (1950)
-
Experimentelle Pharmakologie der Follikelhormone und der Oestrogenen Stilbene
Klinische Wochenschrift (1941)
-
A Colour Reaction of Diethylstilbœstrol (4.4′ dihydroxy-α, β-diethylstilbene)
Nature (1940)
-
Ein Beitrag zur Spezifit�t synthetischer Oestrogene
Die Naturwissenschaften (1939)
-
Experimentelle Untersuchungen Über die Wirkung Eines Synthetischen Follikulinersatzstoffes Diäthyldioxy-Stilben (Cyren) auf die Periphere Blutversorgung
Klinische Wochenschrift (1939)
