Abstract
THE recent announcement by Karrer, Fritzsche, Ringier and Salomon1 makes it desirable for us to place on record the fact that we have also synthesized racemic α-tocopherol by a rather simpler method, namely, direct condensation of phytol with ψ-cumoquinol by heating a mixture of these two substances in presence of a little zinc chloride. This synthesis, like that of the Swiss workers, while it confirms the view originally expressed by ourselves2and by Fernholz3 that the tocopherols are chroman or coumaran derivatives, nevertheless fails to distinguish between the two types of structure.
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References
NATURE, 141, 1057 (1938).
Bergel, Todd and Work, J. Chem. Soc., 253 (1938); Bergel Jacob, Todd and Work, NATURE, 141, 646 (1938).
Fernholz, J. Amer. Chem. Soc., 60, 700 (1938).
Karrer, Fritzsche, Ringier and Salomon, Helv. chim. Acta, 21, 520 (1938).
Dietzel, Günther and Emte, Naturwiss., 366 (1938).
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BERGEL, F., JACOB, A., TODD, A. et al. Vitamin E Synthesis of α-Tocopherol. Nature 142, 36 (1938). https://doi.org/10.1038/142036a0
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DOI: https://doi.org/10.1038/142036a0
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