Abstract
DURING experiments in this Institute as previously described1,2,3, a spindle-celled sarcoma (Mal. sarcoma 1) was obtained in a mouse after 133 days' treatment with a carcinogenic compound. Mice bearing grafted generations of this tumour showed blood changes to accompany the growth of the grafts, and on five occasions cell-free filtrates giving rise to sarcomas resembling the parent tumour were obtained and grafted for many generations. In the 122nd generation of the original sarcoma, a cell-free filtrate of this tumour, together with blood from the mouse bearing the grafted generation, was introduced into an irradiated mouse, which produced a sarcoma (Mal. Fil. 6) at the site of inoculation. This tumour and its descendants have provided the material for the experiments to be described.
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References
Cook, J. W., J. Chem. Soc., 3277 (1931).
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Parsons, L. D., J. Path. and Bact., 40, 46 (1935).
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PARSONS, D. Changes in the Lymph Glands of Tumour-Bearing Mice. Nature 142, 480 (1938). https://doi.org/10.1038/142480a0
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DOI: https://doi.org/10.1038/142480a0
