Production of Mammary Carcinomas in Mice of a Susceptible Strain by the Synthetic Œstrogen, Triphenyl Ethylene

Abstract

IT is well known that in certain inbred strains of mice, many of the females develop spontaneous mammary tumours. Few or no tumours occur in the males of these strains or in the females spayed before puberty. When, however, these males are injected with Œstrone over prolonged periods, a number develop mammary tumours.