Abstract
THE brief reference to the apparently anomalous nitration of the acetyl derivative of 2-m-xylidine to a 4-nitro derivative and its interpretation in the paper just published by Ingham and Hampson1 makes it desirable to point out that many of the anomalies associated with ortho-substituents (and usually grouped under the heading of ‘ortho effects’) find their explanation in the steric hindrance of resonance discussed by Ingham and Hampson. This view had been arrived at independently in connexion with a systematic study of isomerizations produced by aluminium chloride2. It is hoped to publish an account of the further development of this work in the near future, but meanwhile the following selected illustrations of the more general application of this view may be cited.
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BADDELEY, G. Mesomerism and Orientation. Nature 144, 444 (1939). https://doi.org/10.1038/144444a0
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DOI: https://doi.org/10.1038/144444a0
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