Abstract
THE production of methæmoglobin in the blood by oxidation of hæmoglobin by sulphanilamide has been discussed by Shaffer1, Locke and Mellon2 and Mayer3. Locke and Mellon attribute the oxidizing action to the p-nitroso benzene sulphonamide and not to the hydroxylamine derivative. They further state that the hydroxylamine derivative is not an oxidizing agent at the pH of the blood, and believe that the chemotherapeutic action is due to its power of inactivating catalase (Sevag and Maiweg4).
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References
Shaffer, P. A., Science, 89, 547 (1939).
Locke, A., and Mellon, R. R., Science, 90, 231 (1939).
Mayer, R. L., Bull.l’ Acad. Méd., 117, 727 (1937).
Sevag, M. G., and Maiweg, L., Biochem. Z., 288, 41 (1936).
Brooks, M. M., Proc. Soc. Exp. Biol. Med.. 32, 63 (1934); Calif, and Western Med., 41, 131 (1934): 43, 327 (1935).
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BROOKS, M. Sulphanilamide and Glucose Antidote. Nature 145, 707 (1940). https://doi.org/10.1038/145707b0
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DOI: https://doi.org/10.1038/145707b0
