Evidence of Demethylation in the Animal Body

Abstract

DURING the course of work on the metabolism of synthetic œstrogenic compounds¹ undertaken at this Institute, attention has been directed to the methyl ethers of some of the synthetic œstrogenic phenols. Preliminary experiments have been carried out on 4: 4′-dimethoxy diphenylether and 4-methoxy diphenyl; 4: 4′-dihydroxy diphenylether having been shown to produce full œstrous response when injected at a dose of 100 mgm. into ovariectomized rats, and 4-hydroxy diphenyl shown to have no oelig;strogenic activity at a dose of 100 mgm.²