Abstract
THROUGH the courtesy of Messrs. Barber and Price I have now seen particulars of the tests referred to in their criticism1 of my note2 on the nature of the Feulgen reaction with nucleic acid. It is obvious from their account that they have failed to see the main point of my suggestion, that is, that polymerization, via a nitrogen linkage, between leuco-base of fuchsine and the purines available in hydrolysed chromatin is just as likely to result in a coloured product as the similar polymerization between aldose and leuco-base via an oxygen linkage. Their experiments, though apparently made in good faith, were mainly concerned with certain elementary details of the Feulgen reaction which have no bearing on my suggestion.
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References
Barber, H. N., and Price, J. R., NATURE, 146, 335 (1940).
Semmens, C. S., NATURE, 146, 130 (1940).
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SEMMENS, C. Nature of the Feulgen Reaction with Nucleic Acid. Nature 146, 808 (1940). https://doi.org/10.1038/146808a0
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DOI: https://doi.org/10.1038/146808a0
