Abstract
UNTIL recently, progesterone has been generally regarded as devoid of mammary growth stimulating activity in most species. Its positive action in the mouse appeared to be exceptional1, though doses of 4 mgm. daily were without effect in the rat2. It has lately transpired, however, that massive doses (15 mgm. daily) promote mammary development in the rat3,4. Two progesterone derivatives, desoxycorticosterone (21 - hydroxy - progesterone)5,6, and pregneninolone (anhydro-hydroxy-progesterone)7 have also recently been shown to exhibit mammogenic activity.
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FOLLEY, S. Non-effect of Massive Doses of Progesterone and Desoxycorticosterone on Lactation. Nature 150, 266 (1942). https://doi.org/10.1038/150266a0
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DOI: https://doi.org/10.1038/150266a0
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