Anti-sulphanilamide Activity of 2-Aminopyrimidine-5-carboxylic Acid

Abstract

THE observation of Woods¹, that the anti-bacterial activity of sulphanilamide is inhibited by p-amino-benzoic acid, has been followed from time to time by observations recording a similar anti-sulphanilamide action for other compounds chemically unrelated to p-aminobenzoic acid. Thus Harris and Kohn² have shown that dl-methionine antagonizes sulphanilamide action. Martin and Fisher³ have reported that adenine possesses anti-sulphanilamide activity in mice infected with streptococci comparable with that possessed by p-aminobenzoic acid. Snell and Mitchell⁴ found that adenine, guanine, xanthine and hypoxanthine, as well as dl-methionine, reversed sulphanilamide bacteriostasis of certain lactic acid bacteria, although the results were largely dependent on the particular organism and conditions employed. Anti-sulphanilamide action has also been demonstrated with urethane⁵.