Abstract
Ekeley and Ronzio1 have described a series of coloured compounds which are obtained when aromatic amidines are heated with glyoxal in alkaline solution. The reaction is complex, and the results are uncertain and dependent on the conditions employed. By heating with a very small amount of glyoxal at pH 9 in the presence of a borate buffer, the reaction is made much more sensitive and reliable, and is suitable for the quantitative estimation of amidines down to 1 in 100,0002. The buffer is made up from 4 gm. of boric acid neutralized in hot solution with caustic soda to pH 9, and diluted to 100 ml. The glyoxal reagent is a 0·5 per cent aqueous solution of glyoxal sodium bisulphite
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References
Ekeley, J. B., and Ronzio, A. R., J. Amer. Chem. Soc., 57, 1353 (1935).
Evans, D. G., Fuller, A. T., and Walker, J., Lancet, ii, 523 (1944).
Devine, J., Ann. Trop. Med. and Parasitol., 38, 35 (1944).
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FULLER, A. A Colour Reaction for Aromatic Amidines. Nature 154, 773 (1944). https://doi.org/10.1038/154773a0
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DOI: https://doi.org/10.1038/154773a0
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