Abstract
KELSEY et al.1 have described the preparation and properties of a "quinine degradation product" obtained by incubation of quinine with a suspension of rabbit liver tissue, and Mead and Koepfli2 have reported on the chemical constitution of the product. These workers have not, however, determined whether or not this product is active against malaria parasites. We have therefore carried out the investigations described below on its action against infections of Plasmodium gallinaceum in chicks.
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References
Kelsey, F. E., Geiling, E. M. K., Oldham, F. K., and Dearborn, E. H., J. Pharmacol. and Exp. Ther., 80, 391 (1944).
Mead, J., and Koepfli, J. B., J. Biol. Chem., 154, 507 (1944).
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MARSHALL, P. Loss of Antimalarial Properties in Quinine Degradation Products. Nature 156, 505–506 (1945). https://doi.org/10.1038/156505a0
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DOI: https://doi.org/10.1038/156505a0
