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EFFECT OF SOME FATTY ACIDS ON THE OXYGEN UPTAKE OF MYCOBACT. TUBERCUL. HUM. IN RELATION TO THEIR BACTERICIDAL ACTION

Nature volume 157, pages 306–307 (1946)Cite this article

Abstract

IN connexion with our work1 on antibiotics against Mycobact. tubercul. the need of a rapid standardization method led us to try the Warburg technique for measuring the oxygen consumption. This method has been generally used for similar investigations on faster growing bacteria. We have found the method very satisfactory with Mycobact. tubercul. if a large amount of bacteria (1.5-6 mgm. wet weight) is used in each vessel. The slow growth of these bacteria seems to have discouraged previous workers on antituberculous substances from using this method. However, it has been shown that the oxygen consumption of Mycobact. tubercul. is conveniently measurable with the Warburg technique2,3.

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References

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  8. To be published later.

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Authors and Affiliations

  1. Department of Biochemistry, Medical Nobel Institute, Stockholm

    SUNE BERGSTRÖM &  HUGO THEORELL

  2. Municipal Bacteriological Central Laboratory, Stockholm

    HANS DAVIDE

Authors
  1. SUNE BERGSTRÖM
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  2. HUGO THEORELL
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  3. HANS DAVIDE
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BERGSTRÖM, S., THEORELL, H. & DAVIDE, H. EFFECT OF SOME FATTY ACIDS ON THE OXYGEN UPTAKE OF MYCOBACT. TUBERCUL. HUM. IN RELATION TO THEIR BACTERICIDAL ACTION. Nature 157, 306–307 (1946). https://doi.org/10.1038/157306a0

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