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Use of Normal Human Plasma Fractions in Hæmophilia

Abstract

THE availability of separated human plasma proteins resulting from recent advances in fractionation methods1 has provided the possibility of further investigations into the clotting mechanism in hæmophilia. It is of particular interest to find with which normal plasma fraction is associated the coagulation-promoting substance effective in hæmophilia2, and to make a closer examination of this material. Important results have already been published on this subject3.

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References

  1. Cohn, E. J., et al., J. Clin. Invest., 23, No. 4 (1944).

  2. Van Creveld, S., Maandschr. v. Kindergeneesk., 3, No. 9 (1934). Bendien, W. M., and van Creveld, S., Acta Brevia Neerl., 5, No. 9. (1935); 7, No. 1 (1937); 7, Nos. 6–7 (1937); 8, No. 7 (1938). Amer. J. Dis. Childr., 54, 713 (1937). Acta Medica Scand., 99, No. 1 (1939). Van Creveld, S., and Mastenbroek, G. G. A., Acta Brevia Neerl., 11, No. 10 (1941). Van Creveld, S., Acta Paediatr., 29, No. 1 (1941). Patek, A. J., Jr., and Taylor, F. H. L., J. Clin. Invest., 16, 113 and 741 (1937). Howell, W. H., Bull New York Acad. Med., 15, 3 (1939).

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  3. See Lewis, J. H., Tagnon, W. J., Davidson, Ch. S., Minot, G. R., and Taylor, F. H. J., Blood, 1, No. 2 (1946).

  4. Kekwick, R. A., Mackay, M. E., and Record, B. R., Nature, 157, 629 (1946).

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VAN CREVELD, S., MASTENBROEK, G. Use of Normal Human Plasma Fractions in Hæmophilia. Nature 158, 447 (1946). https://doi.org/10.1038/158447a0

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