Abstract
IT has been known since 1941 that sulphonamides influence the thyroid gland. MacKenzie, MacKenzie and MacCollum1 note that rats on a purified diet containing 1–2 per cent of sulphanilylguanidine show hypertrophy of the thyroid gland. The action is not influenced by yeast, p-aminobenzoic acid, or excess of iodine. Somewhat later2, sulphadiazine, sulphathiazole, sulphapyridine and sulphanilamide were found to produce a similar effect. Basal metabolism is lowered by any sulphonamide, and sulphanilamide is the least active one. Taurog, Chaikoff and Franklin3 showed that sulphonamides and similar products inhibit the formation of diiodotyrosine and thyroxin by living tissue slices of thyroid in vitro, in presence of radioactive inorganic iodine.
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References
MacKenzie, MacKenzie and MacCollum, Science, 94, 518 (1941).
MacKenzie and MacKenzie, Endocrin., 32, 185 (1943).
Taurog, Chaikoff and Franklin, J. Biol. Chem., 161, 537 (1945).
Libermann, D., C.R. Acad. Sci., in the press.
Astwood, J. Pharmacol, and Exp. Therap., 78, 79 (1943).
Nogales, Tarrida and Castello, Medicina Clinica, 6, 420 (1946).
Györgyi, Stiller and Williamson, Science, 98, 518 (1943).
Miller and Roblin, J. Amer. Chem. Soc., 67, 2197 (1945).
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LIBERMANN, D. Sulphonamides and the Thyroid Gland. Nature 158, 557 (1946). https://doi.org/10.1038/158557a0
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DOI: https://doi.org/10.1038/158557a0
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