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Leukotaxine and Histamine

Nature volume 159, pages 841–842 (1947)Cite this article

Abstract

INFLAMMATORY exudates contain a polypeptide, leukotaxine, which has, among other properties, that of inducing increased capillary permeability on intracutaneous injection1,2,3. Other observations suggest that histamine may play a fundamental part in wheal formation of allergic and non-allergic origin4–9. It has therefore been suggested that the active factor in inflammatory exudates is really histamine and not leukotaxine, or that leukotaxine, if it exists, induces an increased permeability of the capillaries only through the mediation of histamine8.

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Authors and Affiliations

  1. Department of Pharmacology, University of Manchester,

    H. CULLUMBINE

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  1. H. CULLUMBINE
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CULLUMBINE, H. Leukotaxine and Histamine. Nature 159, 841–842 (1947). https://doi.org/10.1038/159841b0

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