Effects of an energy and micronutrient supplement on skeletal maturation in undernourished children in Indonesia

Abstract

Objectives: This paper reports the effects of an energy and micronutrient supplement on skeletal maturation of nutritionally at risk infants and toddlers in Pangalengan, Indonesia.

Design: Two cohorts of children were randomly assigned to three treatments: E=1171 kJoule+12 mg iron; M=12 mg iron+209 kJ; S=104 kJ. Supplementation was given for 12 months.

Setting: The sites were six tea plantations in Pangalengan, West Java.

Subjects: A 12-month-old (n=53) and an 18-month-old (n=83) cohort were recruited from day-care-centers. Twenty children that received S belonged to the 12- and 18-month-old cohorts. Inclusion criteria were: no chronic disease; length-for-age ≤−1 standard deviation (s.d.) and weight-for-length between −1 and −2 s.d. of the median of the reference of the World Health Organization.

Methods: Skeletal maturation was measured by X-ray of the left hand and wrist. The number of ossified centers and two different measures of skeletal age (Skel-1 and Skel-2) were the outcome variables measured.

Results: In the 12-month-old cohort, there were intergroup differences 6 and 12 months after baseline. First, the children in the E group were about 2 months more advanced in ossified centers than the children in the S group (P<0.10). At 12 months, the children in the E group were about 3 months more advanced in skeletal age than the children in the M group. M group children were about 2.5 months behind the children in the S group.

Sponsorship: Nestlé Foundation.

European Journal of Clinical Nutrition (2000) 54, Suppl 2, S74–S79