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Clinical accuracy of the MedGem™ indirect calorimeter for measuring resting energy expenditure in cancer patients

European Journal of Clinical Nutrition volume 59, pages 603–610 (2005)Cite this article

Abstract

Objective

To compare, in patients with cancer and in healthy subjects, measured resting energy expenditure (REE) from traditional indirect calorimetry to a new portable device (MedGem™) and predicted REE.

Design

Cross-sectional clinical validation study.

Setting

Private radiation oncology centre, Brisbane, Australia.

Subjects

Cancer patients (n=18) and healthy subjects (n=17) aged 37–86 y, with body mass indices ranging from 18 to 42 kg/m2.

Interventions

Oxygen consumption (VO2) and REE were measured by VMax229 (VM) and MedGem (MG) indirect calorimeters in random order after a 12-h fast and 30-min rest. REE was also calculated from the MG without adjustment for nitrogen excretion (MGN) and estimated from Harris–Benedict prediction equations. Data were analysed using the Bland and Altman approach, based on a clinically acceptable difference between methods of 5%.

Results

The mean bias (MGN–VM) was 10% and limits of agreement were –42 to 21% for cancer patients; mean bias −5% with limits of −45 to 35% for healthy subjects. Less than half of the cancer patients (n=7, 46.7%) and only a third (n=5, 33.3%) of healthy subjects had measured REE by MGN within clinically acceptable limits of VM. Predicted REE showed a mean bias (HB–VM) of −5% for cancer patients and 4% for healthy subjects, with limits of agreement of −30 to 20% and −27 to 34%, respectively.

Conclusions

Limits of agreement for the MG and Harris Benedict equations compared to traditional indirect calorimetry were similar but wide, indicating poor clinical accuracy for determining the REE of individual cancer patients and healthy subjects.

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Authors and Affiliations

  1. Centre for Health Research, Queensland University of Technology, Brisbane, Queensland, Australia

    M M Reeves & D Battistutta

  2. The Wesley Research Institute, Brisbane, Queensland, Australia

    M M Reeves & J Bauer

  3. Australian Centre for Evidence Based Nutrition and Dietetics, University of Newcastle, Newcastle, New South Wales, Australia

    S Capra

  4. Children's Nutrition Research Centre, Royal Children's Hospital, University of Queensland, Brisbane, Queensland, Australia

    P S W Davies

Authors
  1. M M Reeves
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  2. S Capra
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  3. J Bauer
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  4. P S W Davies
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  5. D Battistutta
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Corresponding author

Correspondence to M M Reeves.

Additional information

Guarantor: M Reeves.

Contributors: MMR was responsible for writing the manuscript, initiated and designed the study, carried out data collection, data analysis, interpretation and discussion of results. SC initiated the study and assisted in the design of the study. JB contributed to the study design and assisted with data collection. PSWD and DB contributed to the study design, data analysis, interpretation and discussion of results and manuscript preparation.

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Reeves, M., Capra, S., Bauer, J. et al. Clinical accuracy of the MedGem™ indirect calorimeter for measuring resting energy expenditure in cancer patients. Eur J Clin Nutr 59, 603–610 (2005). https://doi.org/10.1038/sj.ejcn.1602114

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