Abstract
Tryptophane can replace nicotinamide in the nutrition of the growing rat1 and when ingested increases the urinary elimination of nicotinamide derivatives of mammals and man2–6. The site and mechanism of this conversion of tryptophane into nicotinamide are unknown and form the subject of this investigation.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Krehl, W. A., Sarma, P. S., Teply, L. J., and Elvehjem, C. A., J. Nutrition, 31, 85 (1946).
Rosen, F., Huff, J. W., and Perlzweig, W. A., J. Biol. Chem., 163, 343 (1946).
Schweigert, B. S., and Pearson, P. B., J. Biol. Chem., 168, 555 (1947).
Singal, S. A., Sydenstricker, V. P., and Littlejohn, T., Fed. Proc., 6, 422 (1947).
Schweigert, B. S., Pearson, P. B., and Wilkening, M. C., Arch. Biochem., 12, 139 (1947).
Perlzweig, W. A., Rosen, F., Levitas, N., and Robinson, J., J. Biol. Chem., 167, 511 (1947).
Dann, W. J., J. Biol. Chem., 141, 803 (1941).
Mitchell, H. K., and Isbell, E. R., Univ. Texas Pub., 4237, 125 (1942).
Wegner, M. I., Booth, A. N., Elvehjem, C. A., and Hart, E. B., Proc. Soc. Exp. Biol. Med., 45, 769 (1940); 47, 308 (1941).
Shourrie, K. L., and Swaminathan, M., Ina. J. Med. Res., 27, 679 (1940).
Ellinger, P., and Coulson, R. A., Biochem. J., 38, 265 (1944). Ellinger, P., Coulson, R. A., and Benesch, R., Nature, 154, 270 (1944). Ellinger, P., Benesch, R., and Kay, W. W., Lancet, i, 432 (1945).
Najjar, V. A., Holt jun., L. E., Johns, G. A., Medairy, G. C., and Fleischmann, G., Proc. Soc. Exp. Biol. Med., 61, 271 (1946).
Ellinger, P., and Emmanuelowa, A., Lancet, ii, 716 (1946).
Ellinger, P., Abdel Kader, M. M., and Emmanuelowa, A., Brit. J. Exp. Path., 23, 261 (1947).
Ellinger, A., Hoppe Seyler's Z., 43, 325 (1904).
Kotake, Y., Hoppe Seyler's Z., 195, 139 (1931).
Lepkowsky, S., Boboz, E., and Haagen-Smit, A. J., J. Biol. Chem., 149, 195 (1943).
Rosen, F., Huff, J. W., and Perlzweig, W. A., J. Nutrition, 33, 561 (1947).
Guggenheim, M., "Die biogenen Amine", 174 (New York, 1940).
Fildes, P., Brit. J. Exp. Path., 19, 239 (1938).
Barton-Wright, E. G., Biochem. J., 38, 314 (1944).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
ELLINGER, P., KADER, M. Tryptophane as Precursor of Nicotinamide in Mammals. Nature 160, 675–676 (1947). https://doi.org/10.1038/160675b0
Issue date:
DOI: https://doi.org/10.1038/160675b0
