Abstract
THE suppressive action of ‘Mepacrine' on the oxidation of glucose by Plasmodium gallinaceum has recently been described1. Since comparatively large concentrations of the drug (1 in 6,000) were necessary to produce an appreciable inhibition of respiration, it is questionable whether this effect is a measure of the specific antagonistic reaction responsible for the in vivo antimalarial properties of ‘Mepacrine'.
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References
Marshall, P. B., Brit. J. Pharmacol., 3, 1 (1948).
Rubbo, S. D., Brit. J. Exp. Path., 28, 1 (1947).
Wiselogle, F. Y., "Survey of Antimalarial Drugs, 1941–45" (J. W. Edwards, Ann Arbor, Michigan, 1946).
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ALBERT, A., MARSHALL, P. Absence of Correlation between Respiratory Inhibition of Plasmodia by Acridines and Antimalarial Action. Nature 161, 1008–1009 (1948). https://doi.org/10.1038/1611008b0
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DOI: https://doi.org/10.1038/1611008b0
