Abstract
THE recent paper by Woodward1 records the synthesis of polypeptides of very high molecular weight by the polymerization of N-carbonic anhydrides (I). This reaction is a well-known method of preparing polypeptides2,3,4, and Go and Tani5 prepared both a polyglycine of molecular weight about 6,000, and a co-polymer of L-leucine and glycine.
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References
Woodward and Schramm, J. Amer. Chem. Soc, 69, 1551 (1947).
Leuchs, Ber., 39, 857 (1906); 41, 1721 (1908).
Curtius and Sieber, Ber., 55, 1543 (1922).
Wessely et al., Z. physiol. Chem., 146, 172 (1925); 157, 191 (1926); 159, 102 (1926); 170, 167 (1927); Monatshefte, 48, 1 (1927).
Go and Tani, Bull. Chem. Soc. Japan, 14, 510 (1939).
Hanby and Rydon, Biochem. J., 40, 297 (1946).
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HANBY, W., WALEY, S. & WATSON, J. Synthetic Polyglutamic Acid. Nature 161, 132 (1948). https://doi.org/10.1038/161132a0
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DOI: https://doi.org/10.1038/161132a0
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