Abstract
THE preliminary communication of Lehmann1 on the treatment of human tuberculosis with p-amino-salicylic acid led us to undertake a detailed study of this acid. p-Aminosalicylic acid2 is obtained by the reduction of p-nitrosalicylic acid, which itself can be prepared by a variety of methods3. These methods are uniformly laborious and we have consequently investigated alternative methods for its preparation. We find that direct carboxylation of m-aminophenol, using modified Kolbe conditions, gives p-aminosalicylic acid and not p-hydroxyanthranilic acid4.
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References
Lancet, N.Y., 250, 15 (1946).
Seidel and Bittner, Monatsh, 23, 423 (1902). Kondo and Nakajima, J. Pharm. Soc. Japan, 485, 355 (1922).
See, for example, Borsche, Ann., 390, 4 (1912). Ullmann and Wagner, Ann., 355, 360 (1907).
"Beilstein‘s Hdb.", 14, 592.
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MARTIN, D., SPRING, F., DEMPSEY, T. et al. p-Aminosalicylic Acid in the Treatment of Tuberculosis. Nature 161, 435 (1948). https://doi.org/10.1038/161435a0
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DOI: https://doi.org/10.1038/161435a0
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