Abstract
IN a series of papers by Dougherty, White and Chase, it has been claimed that the rate of lymphoid tissue dissolution is under the control of the adrenal cortex1–5, and that injections of pituitary adrenocorticotropic hormone or adrenal cortical extract accelerate this dissolution and release antibody globulin which, it has been claimed by themselves6,2,7,4,5and by other workers8,9 is present in the lymphocytes. The evidence adduced by Dougherty, White and Chase in support of this contention was the histological finding of cellular destruction and increased phagocytic activity in the lymphoid organs, and the reduction of weight of these organs, which they10 and others11–14 had shown to follow such injections. The present work was undertaken to investigate by quantitative methods the action of adrenal cortical extracts on lymphocytes, and to determine whether any direct lytic effect could be demonstrated.
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References
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ROBERTSON, J. Failure of Adrenal Cortical Extracts to Cause Lysis of Living Lymphocytes in vitro. Nature 161, 814 (1948). https://doi.org/10.1038/161814a0
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DOI: https://doi.org/10.1038/161814a0
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