Abstract
Mayer and Kull1 have demonstrated that ‘Pyribenzamine’ and ‘Antistin’ counteract the spreading effect of hyaluronidase, and have claimed, therefore, that these antihistamine drugs exhibit a strong anti-hyaluronidase action. In view of the failure by Swyer2, using an in vitro technique, to confirm a similar claim by Guerra3,4 with respect to a supposed anti-hyaluronidase property of salicylates, it was decided to investigate the effect in vitro of various concentrations of some antibistamine drugs upon the hyaluronidase system.
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References
Mayer, R. L., and Kull, F. C., Proc. Soc. Exp. Biol. and Med., 66, 392 (1947).
Swyer, G. I. M., Biochem. J., 42, 32 (1948).
Guerra, F., Science, 103, 686 (1946a).
Guerra, F., J. Pharmacol, 87, 193 (1946b).
Kass, E. H., and Seastone, C. V., J. Exp. Med., 79, 319 (1944).
McClean, D., and Hale, C. W., Biochem. J., 35, 159 (1941).
Hechter, O., J. Exp. Med., 85, 77 (1947).
Swyer, G. I. M., Biochem. J., 42, 28 (1948).
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MOYNAHAN, E., WATSON, D. Failure of Antihistamine Drugs to Inhibit Hyaluronidase in vitro. Nature 163, 173 (1949). https://doi.org/10.1038/163173a0
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DOI: https://doi.org/10.1038/163173a0
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