Abstract
ASSOCIATED with hypertension in the 'Goldblatt animal', the formation of a pressor polypeptide has been demonstrated. It has been shown by Page and Helmer1 that the action of renin on α2-globulin produces a histidine-rich polypeptide, angiotonin (see also Edman2), which has considerable pressor activity. A peptide having similar activity was obtained by Croxatto and Croxatto3 by the action of pepsin on α2-globulin, and this substance, pepsitensin, was shown to be distinct from angiotonin; and Dawson and Findlay4 have shown the formation of such peptides from haemoglobin in blackwater fever.
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References
Page, I. H., and Helmer, O. M., J. Exp. Med., 71, 29 (1940).
Edman, P., Ark. f. Kem. Min. u. Geol., 22 A, No. 3, 1 (1945).
Croxatto, H., and Croxatto, R., Science, 95, 101 (1942).
Dawson, J., and Findlay, G. M., Ann. Trop. Med. Parasit., 41, 306 (1947).
Northrop, J. H., Harvey Lectures, 229 (1934–35).
Plentl, A. A., and Page, I. H., J. Biol. Chem., 158, 49 (1945).
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CHATTAWAY, F., DAWSON, J. Pressor Material Prepared from Hæmoglobin. Nature 163, 531 (1949). https://doi.org/10.1038/163531a0
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DOI: https://doi.org/10.1038/163531a0
