Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News
  • Published:

Mechanism of the Feufgen Nucleal Reaction

Abstract

In a previous paper1 from these laboratories, it was shown that the mechanism for the Dische2 diphenylamine reaction for deoxyribonucleic acid depends upon the conversion by acid treatment of the depxyribose component into w-hydroxy lævulinic aldehyde, which then coupled with diphenylamine to give a blue dye with a characteristic absorption band. Extension of this work with Dr. Ethel Teece has led to the isolation in 10 per cent yield of an amorphous blue complex possessing the characteristic band.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Deriaz R. E., Stacey, M., Teece, E. G., and Wiggins, L. F., Nature, 157, 740 (1946).

    Article  ADS  Google Scholar 

  2. Dische, Z., Microchemie, 8, 4 (1930).

    CAS  Google Scholar 

  3. Feulgen, R., and Rosenbeck, H., Z. physiol. Chem., 135, 203 (1924).

    Article  CAS  Google Scholar 

  4. Danielli, J. F., Symposia Soc. Exp. Biol., 1, 101 (1947).

    Google Scholar 

  5. Stedman, E., and Stedman, E., Biochem. J., 43, xxiii (1948).

    CAS  PubMed  Google Scholar 

  6. Tobie, W. C., Indust. Eng. Chem., 14 (5), 405 (1942).

    CAS  Google Scholar 

  7. Wieland H., and Scheuing, G., Ber., 54, 2527 (1921); see also Rumpf, P., Ann. Chim., 3, 327 (1935).

    Google Scholar 

  8. Widström, G., Biochem. Z., 199, 298 (1928).

    Google Scholar 

  9. Gulland, J. M., and Jordan, D. O., J. Chem. Soc., 1129 (1947).

  10. Stedman, E., and Stedman, E., Symp. Soc. Exp. Biol., 1, 232 (1947), and previous publications.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

OVEREND, W., STACEY, M. Mechanism of the Feufgen Nucleal Reaction. Nature 163, 538–540 (1949). https://doi.org/10.1038/163538b0

Download citation

  • Issue date:

  • DOI: https://doi.org/10.1038/163538b0

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing