Abstract
IT was shown by Quastel and Wheatley1 that slices of brain tissue are able to oxidize l-glutamic acid in the absence of glucose. Recent experiments by Mayer-Gross and Walker2 have shown that the injection of glutamic acid and other amino-acids relieves the hypoglycæmic coma produced by insulin—an effect which apparently does not depend entirely upon the associated rise in the blood-glucose level.
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References
Quastel, J. H., and Wheatley, A. H. M., Biochem. J., 26, 725 (1932).
Mayer-Gross, W., and Walker, J. W., Biochem. J., 44, 92 (1949).
Krebs, H. A., Biochem. J., 43, 51 (1948).
Stern, J. R., Eggleston, L. V., Hems, R., and Krebs, H. A., Biochem. J., 44, 410 (1949).
Weil-Malherbe, H., Biochem. J., 30, 665 (1936).
Krebs, H. A., and Eggleston, L. V., Biochem. J., 44, vii (1949).
Nachmansohn, D., John, H. M., and Waelsch, H., J. Biol. Chem., 150, 485 (1943).
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DAWSON, R. Effect of Insulin Hypoglycæmia on Brain Glutamate. Nature 164, 1097 (1949). https://doi.org/10.1038/1641097a0
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DOI: https://doi.org/10.1038/1641097a0
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