Paralysing Activity of Some Heterocyclic Decamethylene-xω-bis Quaternary Ammonium Salts

Abstract

THE work of Barlow and Ing and of Paton and Zaimis, recently reviewed by Paton¹, has established that the distance separating a pair of quaternary nitrogen atoms corresponding to optimal paralysing activity for mammals approximates to that occupied by the decamethylene chain. The present work was undertaken with the object of investigating the effect of varying the groups attached to a pair of quaternary nitrogen atoms, separated by a decamethylene chain, upon paralysing and associated activity. In modifying the groups attached to these quaternary nitrogen atoms, we aimed at simulating various chemical features of the tubocurarine molecule.