Abstract
IT has been suggested1,2, on the basis of kinetic measurements, that the fluorophosphonates inhibit esterases by virtue of a highly specific affinity for the active centres of this group of enzymes. Preliminary experiments with di-isopropyl fluorophosphonate containing phosphorus-32 have given results which are in accordance with this view.
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References
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Saunders, B. C., and Worthy, T. S., Nature, 163, 797 (1949).
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BOURSNELL, J., WEBB, E. Reaction of Esterases with Radioactive Di-isopropyl Fluorophosphonate. Nature 164, 875 (1949). https://doi.org/10.1038/164875a0
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DOI: https://doi.org/10.1038/164875a0
