Duration of Protection by Antihistaminics in Anaphylactic Shock

Abstract

Traina and Aleksandrowicz reported recently¹ that, in contrast to the findings of Pasteur, Vallery-Radot, Halpern and Holtzer², guinea pigs which survived a previous exposure to anaphylactic shock during antihistaminic treatment were protected against a second challenging injection of the sensitizing agent given one day later. These experiments were carried out on thirteen guinea pigs, of which two were used for control. The implication of such a result might become extremely broad from the point of view of the mechanism of action of antihistaminic drugs.