Abstract
WHEN streptomycin is administered by mouth, only a small proportion is absorbed, and very high concentrations of the drug can be obtained in the stools, 2–9 mgm. per gm. having been recorded without toxic symptoms1,2. It seemed of interest, therefore, to determine whether such concentrations could have any effect on the motility of the gut other than by virtue of the bacteriostatic action.
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References
Elias, W. F., and Durso, J., Science, 101, 589 (1945).
James, U., and Kramer, I. R. H., Lancet, ii, 555 (1948).
Schild, H. O., Brit. J. Pharmacol., 2, 189 (1947).
Waksman, S. A., “Microbial Antagonisms and Antibiotic Substances”, 292 (2nd edit. Commonwealth Fund, K.Y., 1947).
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CAMPBELL, J., KRAMER, I. Effect of Streptomycin Preparations on Gut Responses to Contractor Substances. Nature 165, 78–79 (1950). https://doi.org/10.1038/165078a0
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DOI: https://doi.org/10.1038/165078a0
