Abstract
THAT 2-hydroxypyrimidine, a simple derivative of a much investigated series, should be incorrectly described in the literature is unexpected. Nevertheless, the properties attributed to this substance by Johnson and Joyce1, the only workers who have claimed its synthesis, make it unlikely that it has ever been prepared. As the 2-hydroxy-group is present in the biologically important pyrimidines (cytosine, uracil, thymine), it is important to have authentic 2-hydroxypyrimidine available for the interpretation of spectra and for biochemical and biological comparisons.
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References
Johnson and Joyce, J. Amer. Chem. Soc., 37, 2163 (1915). Cf. Beilstein's “Handbuch”, 4th ed., 24, 1st supp., 231.
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BROWN, D. 2-Hydroxypyrimidine. Nature 165, 1010 (1950). https://doi.org/10.1038/1651010a0
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DOI: https://doi.org/10.1038/1651010a0
