Abstract
IN the study of the mechanism of epidermal carcinogenesis, it is perhaps not surprising that attention has been mainly directed to the epithelium of the epidermis itself. Nevertheless, changes occur in the dermis and subcutis which can be distinguished from the effects of non-specific irritants, and it has been suggested that these changes are of importance in the carcinogenic reaction1. As it is now technically possible to make pure epidermal grafts2, the opportunity has been taken to test this hypothesis by transferring the epidermis of a carcinogen-treated site to an untreated body-site, and vice versa.
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References
Orr, J. W., J. Path. Bact., 46, 495 (1938).
Billingham, R. E., and Medawar, P. B. (unpublished); cf. Heredity, 2, 29 (1948).
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BILLINGHAM, R., ORR, J. & WOODHOUSE, D. Epidermal Transplantation during Chemical Carcinogenesis. Nature 166, 1080 (1950). https://doi.org/10.1038/1661080a0
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DOI: https://doi.org/10.1038/1661080a0
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